APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability
Posted inNeurology news Otorhinolaryngology

APOE ε4, Age and Sex Converge to Disturb Anterior Olfactory Nucleus Physiology: Electrophysiologic Evidence for Early Alzheimer’s Vulnerability

In vivo awake recordings in transgenic mice show APOE ε4 reduces neuronal excitability in the anterior olfactory nucleus (AON); adult females are more excitable than males (a sex difference lost with aging), while aging amplifies network oscillatory power — revealing interactions that may underlie early olfactory deficits in Alzheimer’s disease.
AI-Driven Quantitative CT Reveals Higher Relative Cardiovascular Risk from Coronary Plaque in Women: Insights from the CONFIRM2 Registry
Posted inAI Cardiology Specialties

AI-Driven Quantitative CT Reveals Higher Relative Cardiovascular Risk from Coronary Plaque in Women: Insights from the CONFIRM2 Registry

AI-based quantitative CT analysis demonstrates that coronary plaque features, while more prevalent in men, confer a disproportionately higher relative risk of major adverse cardiovascular events in women, highlighting the need for sex-specific risk assessment and targeted interventions.