polygenic risk score – Page 2

Integrating Metabolomics and Polygenics with SCORE2: A New Frontier in Cardiovascular Risk Stratification

By MedXY 01/05/2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented events through improved clinical reclassification.

Cardiology news Public Health

Synergistic Integration of Metabolomics and Polygenic Scores Doubles the Impact of Cardiovascular Risk Prediction Models

By MedXY 01/05/2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events in population-wide screening programs.

Cardiology news

Beyond Vagal Tone: Genetic Predisposition and Physical Fitness Drive Profound Bradycardia in Elite Athletes

By MedXY 12/24/2025

A comprehensive study of elite endurance athletes reveals that resting bradycardia (≤40 bpm) is common and driven by both fitness and a lower polygenic risk score for heart rate. These findings suggest that genetics may predispose individuals to athletic success and sinus node remodeling.

news Oncology Urology

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History

By MedXY 12/17/2025

This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.

Cardiology news

Polygenic Risk Score Predicts Peripheral Artery Disease and Major Adverse Limb Events but Offers Modest Incremental Discrimination

By MedXY 12/02/2025

In pooled analyses of six TIMI trials (n=68,816), a validated PAD polygenic risk score was independently associated with prevalent PAD (OR per 1-SD 1.15) and incident major adverse limb events (HR per 1-SD 1.30), but added only modest improvement in risk discrimination beyond clinical factors.

news Orthopedics Rheumatology

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms

By MedXY 11/02/2025

Partitioning a knee osteoarthritis polygenic score into BMI-associated and BMI-independent components clarifies genetic contributions, improves interpretability, and offers a path to tailored prediction and prevention.

Cardiology news

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations

By MedXY 10/30/2025

A large-scale multi-ancestry genetic study confirms consistent associations between LDL cholesterol levels and coronary artery disease risk across six global ancestries, highlighting the generalizability of LDL-C lowering interventions beyond European populations.

Clinical Updates Neurology news Specialties

Advancing Alzheimer’s Risk Prediction: Multi-Ancestry Polygenic Risk Scores in Hispanic Populations

By MedXY 08/07/2025

Multi-ancestry polygenic risk scores significantly improve Alzheimer’s disease risk prediction in Hispanic populations compared to traditional single-ancestry models and APOE genotyping alone.