Histidine-Rich Glycoprotein as a Modulator of Platelet Adhesion and Aggregation: Mechanistic Insights and Clinical Implications
Histidine-rich glycoprotein (HRG) directly modulates platelet adhesion and aggregation by binding platelet receptors GPIbα and GPIIb/IIIa, competing with key ligands VWF and fibrinogen, thus attenuating thrombus formation; reduced HRG in sepsis and COVID-19 correlates with heightened platelet reactivity.