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Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder

Posted inDiabetes & Endocrinology news Psychiatry

Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder

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By MedXY 05/05/2026

In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dysfunction.

Neuropsychiatric Symptoms and Their Impact on Daily Functioning in Cognitively Unimpaired Older Adults

Posted inClinical Updates Neurology news Specialties

Neuropsychiatric Symptoms and Their Impact on Daily Functioning in Cognitively Unimpaired Older Adults

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By MedXY 08/02/2025

Neuropsychiatric symptoms such as decreased motivation and emotional dysregulation significantly impair daily functioning in older adults without cognitive impairment, highlighting the need for early identification and intervention.

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