Mitochondrial dysfunction

Mitochondrial Rescue in HFpEF: Elamipretide Restores Skeletal Muscle Performance in a Rat Model

By MedXY 06/15/2026

Elamipretide improved skeletal muscle force, titin phosphorylation, and atrophy in a HFpEF rat model, supporting cardiolipin stabilization as a promising mitochondrial-targeted strategy.

Cardiology Internal Medicine news

Can a Mitochondrial “Membrane Stabilizer” Restore Muscle Function in HFpEF? New Rat Data on Elamipretide

By MedXY 06/15/2026

In a HFpEF rat model, elamipretide improved skeletal muscle force, reduced titin hyperphosphorylation, and prevented atrophy, supporting cardiolipin stabilization as a promising metabolic strategy.

Neurology news Specialties

APOE ε4 Allele as an Independent Predictor of Survival in Parkinson’s Disease Patients

By MedXY 10/21/2025

The APOE ε4 allele significantly reduces survival in Parkinson's disease patients independently of dementia, linked to mitochondrial dysfunction and ER stress in PD models.

Infectious Diseases Internal Medicine news Respiratory Specialties

Unraveling Mitochondrial Dysfunction as a Key Pathological Feature in Long COVID Syndrome

By MedXY 08/30/2025

Long COVID patients exhibit distinct mitochondrial bioenergetic impairments, with altered ATP synthase function correlating with clinical symptoms and quality of life, implicating mitochondrial dysfunction in its pathogenesis.