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LCK

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揭示SRSF1-LCK剪接轴:免疫性血小板减少症中调节性T细胞受损的新机制
Posted inAllergy & Immunology Clinical Updates Hematology-Oncology

Unraveling the SRSF1-LCK Splicing Axis: A Novel Mechanism Underlying Regulatory T-Cell Impairment in Immune Thrombocytopenia

Posted by By MedXY 11/07/2026
Reduced expression of splicing factor SRSF1 disrupts LCK exon 8 inclusion, impairing TCR signaling and regulatory T-cell induction, thereby contributing to immune dysregulation in immune thrombocytopenia.
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