iPSC – Medxy AI

Patient-Derived Neuronal Synapse Deficits Predict Brain Network Abnormalities and Cognitive Impairment in Schizophrenia

By MedXY 05/15/2026

A multimodal translational study links genetically driven synaptic deficits in patient-derived neurons to cortical structure, electrophysiology, and cognition in schizophrenia, supporting biologically informed stratification of cognitive impairment.

Anesthesiology Neurology news

The Hidden Driver of Chronic Pain: How Macrophages Fuel Neuropathic Symptoms

By MedXY 03/27/2026

Researchers using human stem cell models have discovered that macrophages actively amplify the electrical signals of damaged nerves, driving the spontaneous pain characteristic of neuropathy, offering a new target for non-opioid pain relief.

Anesthesiology Neurology news

Neuro-Immune Crosstalk: Macrophages Directly Amplify Spontaneous Activity in Damaged Human Sensory Neurons

By MedXY 03/22/2026

A groundbreaking human iPSC-derived co-culture study reveals that macrophages respond to neuronal injury by adopting a pro-algesic state, directly intensifying spontaneous neuronal firing—a key driver of chronic neuropathic pain and a novel target for future analgesics.