Intracranial Hemorrhage

Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Insights from the TEMPO-2 Trial

By MedXY 04/29/2026

Secondary analysis of TEMPO-2 trial data reveals intracranial hemorrhage in minor stroke patients increases 90-day mortality risk threefold, with higher hemorrhage rates in tenecteplase-treated patients despite most bleeds being non-symptomatic.

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Lower-than-Expected Hemorrhage Risk From Unruptured Brain AVMs: MARS Clarifies Natural History and Key Predictors

By MedXY 12/12/2025

The MARS multicenter cohort (n=3030) found a lower annual intracranial hemorrhage risk (1.40%/yr) for unruptured brain AVMs than commonly cited. Older age, associated arterial aneurysms, and cerebellar/deep supratentorial location increased risk.

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Bridging IV Alteplase Before EVT Modestly Raises Intracranial Hemorrhage Risk — But Net Clinical Impact Is Complex

By MedXY 12/11/2025

An IPD meta-analysis of six randomized trials (2313 patients) found IV alteplase before EVT modestly increased intracranial hemorrhage—particularly parenchymal hematoma—yet ICH risk must be balanced against IVT-associated improvements in reperfusion and potential clinical benefit.

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Thrombolysis Before Thrombectomy May Raise ICH Risk After Stroke: A Comprehensive Review of Recent Evidence

By MedXY 08/19/2025

A meta-analysis of over 2000 stroke patients found that intravenous thrombolysis (IVT) before endovascular treatment (EVT) modestly increases intracranial hemorrhage (ICH) risk, especially in patients with elevated glucose and blood pressure, though functional benefits may still outweigh risks.