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IL-10 autoantibodies

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Neutralising Autoantibodies against IL-10 Linked to Severe Pediatric Inflammatory Bowel Disease and HLA-DRB1*01:03 Allele
Posted inGastroenterology news Pediatrics

Neutralising Autoantibodies against IL-10 Linked to Severe Pediatric Inflammatory Bowel Disease and HLA-DRB1*01:03 Allele

Posted by By MedXY 08/12/2026
A multicategory study reveals 2.5% of pediatric IBD patients harbor IL-10-neutralising autoantibodies associated with severe disease and HLA-DRB1*01:03 allele, underscoring a distinct pathogenic subgroup.
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Unveiling the Role of IL-10-Neutralising Autoantibodies in Pediatric-Onset Inflammatory Bowel Disease: Prevalence, Persistence, and Clinical Implications
Posted inGastroenterology news Pediatrics

Unveiling the Role of IL-10-Neutralising Autoantibodies in Pediatric-Onset Inflammatory Bowel Disease: Prevalence, Persistence, and Clinical Implications

Posted by By MedXY 07/10/2026
This study reveals that IL-10-neutralising autoantibodies occur in 2.1% of pediatric IBD cases without monogenic causes, persist over years, and may define a distinct clinical subgroup with specific therapeutic needs.
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