GWAS – Medxy AI

Unraveling IBS Genetics: Insights into Cardiometabolic and Triglyceride-Linked Mechanisms from a Large GWAS Meta-Analysis

By MedXY 07/13/2026

A genome-wide meta-analysis of 2.8 million individuals reveals genetic links between irritable bowel syndrome, brain-gut pathways, and cardiometabolic traits, highlighting novel therapeutic targets involving triglyceride metabolism.

Neurology news Pathology & Lab Medicine/Bệnh học

New Genetic Modifiers in Autosomal Dominant Alzheimer’s Disease Link Aβ, Tau, TDP-43, and Vascular Biology to Clinical Variability

By MedXY 06/03/2026

A genome-wide association study identified CNIH4, CCNG1, and RHOJ as genetic modifiers of autosomal dominant Alzheimer’s disease, with associations spanning disease risk, age at onset, fluid biomarkers, and neuroimaging phenotypes.

Cardiology Clinical Updates news

Decoding the Genetic Complexity of Bicuspid Aortic Valve: From Genome-Wide Discovery to Clinical Risk Stratification

By MedXY 03/02/2026

This review synthesizes the landmark 2026 findings by Thériault et al., identifying 36 genomic loci and a significant polygenic contribution to bicuspid aortic valve, offering new insights into cardiac morphogenesis and clinical risk prediction.

Internal Medicine news Psychiatry

Unraveling Genetic Links Between Problematic Alcohol Use and Psychiatric Disorders: Insights from Large-Scale Genomic Analyses

By MedXY 10/30/2025

This study reveals significant shared genetic architectures between problematic alcohol use and various psychiatric disorders, identifying key genes like TTC12 and ANKK1 that may underlie their comorbidity.