dose-response – Medxy AI

Diabetes & Endocrinology news Public Health

Incidental Physical Activity Intensity and Type 2 Diabetes Risk: Insights from a Large Wearable-Based Cohort Study

By MedXY 09/30/2026

This UK Biobank study reveals that moderate and vigorous incidental physical activity significantly reduce type 2 diabetes risk, with vigorous activity providing greater benefits per minute than lower intensities.

Clinical Updates news

Dose-Dependent Effects of Produce Prescriptions: Insights from a Randomized Community Trial and Broader Evidence

By MedXY 09/24/2026

This review synthesizes evidence on produce prescription dosing, highlighting a randomized trial demonstrating dose-dependent improvements in redemption, food security, and fruit/vegetable intake, contextualized within the evolving literature on nutritional interventions for food insecurity.

Diabetes & Endocrinology news

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study

By MedXY 07/03/2026

This real-world study demonstrates a dose-dependent increase in suboptimal thyroid hormone control among adults treated with levothyroxine, emphasizing the need for enhanced TSH monitoring in patients on higher doses.

Internal Medicine news Psychiatry Rehabilitation Medicine

How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target

By MedXY 11/08/2025

A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges' g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches a minimally important symptom change.

news Pediatrics Psychiatry

Decoding the Optimal Aerobic Exercise Dose for Alleviating Depression in Youth: Evidence from a Meta-Analysis

By MedXY 10/12/2025

Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.

Clinical Updates Family Medicine & Nutrition news Specialties

How Evening Exercise Timing and Intensity Impact Sleep Quality: Insights from a Large-Scale Biometric Study

By MedXY 09/06/2025

This large cohort study reveals that late and strenuous evening exercise delays sleep onset, shortens sleep duration, lowers sleep quality, and alters autonomic function. Exercising at least 4 hours before sleep or opting for lighter intensity mitigates these effects.