Baseline Deep Capillary Plexus Ischemia as a Superior Predictor of Early Diabetic Retinopathy Complications Relative to Foveal Avascular Zone Enlargement

Baseline Deep Capillary Plexus Ischemia as a Superior Predictor of Early Diabetic Retinopathy Complications Relative to Foveal Avascular Zone Enlargement

Deep capillary plexus ischemia quantified by geometric perfusion deficit predicts earlier and higher risk of diabetic retinopathy complications than foveal avascular zone enlargement, underscoring GPDd's clinical utility as a biomarker for personalized monitoring.
Deep Capillary Plexus Defects Emerge as a Universal Biomarker for Retinal Ischemia Across All Retinal Regions in Diabetic Retinopathy

Deep Capillary Plexus Defects Emerge as a Universal Biomarker for Retinal Ischemia Across All Retinal Regions in Diabetic Retinopathy

Novel OCTA biomarkers reveal that geometric perfusion deficits in the deep capillary plexus serve as robust predictors of retinal nonperfusion across posterior, peripheral, and total retinal regions, while foveal avascular zone enlargement specifically reflects posterior ischemic changes in diabetes.