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Breaking Resistance in Gynaecological Clear Cell Carcinoma: Pembrolizumab plus Lenvatinib Achieves 40% Response Rate in LARA Trial
Posted innews Oncology

Breaking Resistance in Gynaecological Clear Cell Carcinoma: Pembrolizumab plus Lenvatinib Achieves 40% Response Rate in LARA Trial

Posted by By MedXY 02/18/2026
The Phase 2 LARA trial demonstrates that combining pembrolizumab and lenvatinib yields a 40% objective response rate in recurrent gynaecological clear cell carcinoma, offering a potential new standard for this historically chemo-resistant and microsatellite-stable malignancy.
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Novel Heparanase Inhibitor LMW-DSS Shows Promise in Preventing Breast Cancer Metastasis by Targeting Migration and Angiogenesis
Posted inClinical Updates Oncology

Novel Heparanase Inhibitor LMW-DSS Shows Promise in Preventing Breast Cancer Metastasis by Targeting Migration and Angiogenesis

Posted by By MedXY 09/30/2025
Low-molecular-weight dextran sulfate sodium (LMW-DSS), a new heparanase inhibitor, effectively prevents breast cancer metastasis in mice by inhibiting cancer cell migration and angiogenesis, offering a promising therapeutic approach with minimal bleeding risk.
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  • Silver Diamine Fluoride: A Breakthrough Noninvasive Therapy for Severe Early Childhood Caries in US Children
  • Persistent High Rates of Head CT in Pediatric Mild Traumatic Brain Injury: Variability Among Hospital Types and Implications for Practice
  • Behavioral Interventions in Pediatric Type 1 Diabetes: Optimizing Glycemic Control Through Family-Centered, Multicomponent Strategies
  • Enhancing Pediatric Literacy Promotion for Latino Families: Efficacy of Text Messaging and Resource Referrals in a 3-Arm Randomized Controlled Trial
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