Pediatrics – Page 20

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial

By MedXY 08/04/2025

A multisite RCT found no difference in time to full enteral feeds between donor human milk and formula in moderate to late preterm infants, but formula was associated with faster weight regain.

Allergy & Immunology Medical News news Pediatrics Specialties

Peanut Intake in Infants Remains Low Despite Updated Allergy Prevention Guidelines

By MedXY 08/04/2025

Despite recommendations for early allergen introduction, peanut intake among US infants remains low, with significant disparities by age and ethnicity. Tree nut and egg consumption trends also reveal notable demographic and temporal differences.

Clinical Updates news Pediatrics Specialties

Does Treating Older Siblings Enhance the Impact of Azithromycin on Infant Survival? Insights from a Cluster-Randomized Trial in Niger

By MedXY 08/04/2025

Mass azithromycin administration to both infants and older children reduced infant mortality more than treating infants alone, with potential spillover benefits from treating older siblings.

Clinical Updates Infectious Diseases news Pediatrics

Optimizing Daptomycin Use in Japanese Pediatric Patients: The Critical Roles of Dose and Renal Function

By MedXY 08/04/2025

A multicenter study in Japan found that adequate daptomycin dosing significantly improves clinical outcomes in pediatric patients, while adverse events can occur regardless of renal function.

Clinical Updates Gastroenterology Internal Medicine news Pediatrics

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation

By MedXY 08/04/2025

Perinatal antibiotic exposure in preterm infants disrupts gut microbiota composition, increasing pathogenic bacteria and reducing beneficial species, with implications for infection risk and the protective role of breastfeeding.

Clinical Updates news Pediatrics Respiratory

Disparities in Inpatient Antibiotic Use for Pediatric Pneumonia: Minority and Low-Opportunity Children at Higher Risk of Overtreatment

By MedXY 08/04/2025

Minority children and those from lower socioeconomic backgrounds receive significantly more and broader-spectrum antibiotics for pneumonia during hospitalization than non-Hispanic White counterparts, contrary to outpatient trends.

Medical News news Pediatrics Specialties

Understanding Early Puberty in Children: Causes, Risks, and Prevention

By MedXY 08/03/2025

This article explores the causes, implications, and prevention strategies for early puberty in children, supported by clinical insights and expert recommendations.

Family Medicine & Nutrition Medical News news Pediatrics Respiratory Specialties

Ibuprofen vs. Acetaminophen: Which Fever Reducer is Right for You?

By MedXY 08/03/2025

Explore the differences, uses, and safety of ibuprofen and acetaminophen for managing fever effectively.

Clinical Updates Internal Medicine news Pediatrics Specialties

Oral Iptacopan Monotherapy in Paroxysmal Nocturnal Haemoglobinuria: 48-Week Outcomes from APPLY-PNH and APPOINT-PNH Phase 3 Trials

By MedXY 08/03/2025

Oral iptacopan provides sustained haemolysis control and improved haemoglobin in PNH patients over 48 weeks, with a favorable safety profile, supporting its role as a new therapeutic option.

Clinical Updates news Pediatrics Respiratory Specialties

Impact of Maternal Pertussis Vaccination on Infant Immune Responses: Insights from the GaPS Trial in The Gambia

By MedXY 08/02/2025

A phase 4 trial in The Gambia finds that maternal Tdap-IPV vaccination is safe and provides early infant protection, but modestly blunts immune responses to whole-cell pertussis vaccines without compromising overall immunogenicity.

Allergy & Immunology Clinical Updates Dermatology Pediatrics Specialties

Prademagene Zamikeracel: A Breakthrough Gene Therapy for Chronic Wounds in Recessive Dystrophic Epidermolysis Bullosa (RDEB)

By MedXY 08/02/2025

A phase 3 trial demonstrates prademagene zamikeracel significantly accelerates healing and reduces pain in large, chronic RDEB wounds, offering a promising gene therapy with a favorable safety profile.

Clinical Updates news OB/GYN & Women's Health Pediatrics Specialties

Trimethoprim–Sulfamethoxazole in Pregnancy: No Impact on Birth Weight in a Zimbabwean RCT

By MedXY 08/01/2025

A large randomized trial in Zimbabwe found that trimethoprim–sulfamethoxazole prophylaxis during pregnancy did not significantly increase birth weight or reduce adverse outcomes.

Anesthesiology Clinical Updates Critical Care news Pediatrics Specialties

Inhaled Isoflurane: A Noninferior Alternative to Midazolam for Pediatric ICU Sedation

By MedXY 07/31/2025

A multicenter phase 3 trial finds inhaled isoflurane as effective as intravenous midazolam for sedation in mechanically ventilated children, with added benefits of reduced opioid use and faster extubation.

Family Medicine & Nutrition news Pediatrics Public Health Specialties

Sweetener Consumption and Genetic Predisposition: New Insights into Early Puberty Risk in Children

By Dr.Paul 07/31/2025

Sweetener intake, especially aspartame and sucralose, is linked to increased risk of early puberty in genetically predisposed children, with notable sex-specific differences

Clinical Updates Medical News Pediatrics Public Health Specialties

Aluminum-Adjuvanted Vaccines in Early Childhood and Risk of Chronic Autoimmune, Allergic, and Neurodevelopmental Disorders: Insights from a Danish Nationwide Cohort Study

By MedXY 07/31/2025

A comprehensive Danish cohort study finds no evidence linking early childhood aluminum-adsorbed vaccines to increased risks of autoimmune, allergic, or neurodevelopmental disorders, supporting vaccine safety.

Internal Medicine Medical News Pediatrics Specialties

FDA Approves Sephience: A New Oral Therapy for Phenylketonuria

By MedXY 07/30/2025

The FDA has approved Sephience, an oral therapy for phenylketonuria (PKU), offering a novel treatment option for both children and adults with this rare metabolic disorder.

Clinical Updates news Pediatrics Specialties

EMA Recommends First Oral On-Demand Therapy for Hereditary Angioedema: A Paradigm Shift in Acute Attack Management

By MedXY 07/30/2025

EMA endorses sebetralstat, the first oral on-demand therapy for hereditary angioedema, following positive results from the KONFIDENT phase 3 trial, offering a more convenient and rapid treatment option for acute attacks.

Gastroenterology Infectious Diseases Medical News news Pediatrics Specialties

Is There a Norovirus Vaccine on the Horizon? Scientific Progress, Challenges, and Future Directions

By MedXY 07/30/2025

Norovirus vaccines show promise in clinical trials, but scientific and logistical challenges remain. No approved vaccine exists yet, though novel approaches, including oral pills, are advancing development.

Clinical Updates Infectious Diseases Medical News Pediatrics Respiratory Specialties

Influenza-Associated Acute Necrotizing Encephalopathy in US Children

By MedXY 07/30/2025

A multicenter US study highlights the devastating burden of influenza-associated acute necrotizing encephalopathy in children, with high mortality and disability rates despite aggressive therapy, underscoring the urgent need for prevention and standardized management.

Clinical Updates news Pediatrics Specialties

Muscle Strength as a Key Determinant of Metabolic Risk in Paediatric Obesity: New Evidence from Milan

By MedXY 07/30/2025

Stronger leg muscles are linked to significantly lower risk of metabolic syndrome in children and adolescents with obesity, highlighting the importance of muscular fitness in paediatric metabolic health.