Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management
Posted inNeurology news Radiology

Neural Connectivity Patterns Predict Acupuncture Response in Migraine: A Step Toward Personalized Pain Management

This randomized clinical trial demonstrates that real acupuncture significantly reduces migraine frequency and disability compared to sham acupuncture. Crucially, baseline brain connectivity patterns within the default mode and subcortical networks can predict individual treatment responses, offering a potential biomarker for personalized neuromodulatory therapy.
Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology
Posted inNeurology news

Redefining CTE: New Autopsy Evidence Links Repetitive Head Impact to Extensive Spinal Cord Pathology

A landmark autopsy study reveals that Chronic Traumatic Encephalopathy (CTE) involves extensive spinal cord pathology, including tau, TDP-43, and amyloid-β deposits. These findings suggest that repetitive head impacts trigger a widespread encephalomyelopathy, potentially explaining the diverse motor symptoms observed in at-risk individuals.
Tau Pathology Acts as a Switch: How Soluble Amyloid Drives Early Metabolic and Neuropsychiatric Symptoms in Alzheimer’s Disease
Posted inNeurology news Psychiatry

Tau Pathology Acts as a Switch: How Soluble Amyloid Drives Early Metabolic and Neuropsychiatric Symptoms in Alzheimer’s Disease

Recent clinical evidence reveals that soluble amyloid-beta oligomers, rather than traditional plaques, drive glucose dysregulation and depression in early Alzheimer’s disease. Crucially, these associations are modulated by tau pathology, suggesting that tau staging is essential for identifying metabolic and psychiatric vulnerability in the AD spectrum.