High-Level Highlights
This Phase 2 nonrandomized clinical trial provides evidence that a condensed 5-day preoperative radiation therapy (RT) regimen (30 Gy in 5 fractions) for high-risk soft tissue sarcoma (STS) achieves a 2-year local control rate of 92.4%.
Late grade 2 or higher radiation toxic effects occurred in only 18.9% of patients at the 2-year mark, suggesting that the shorter course does not result in prohibitive long-term morbidity.
