Many primary aldosteronism (PA) patients display aldosterone levels within normal ranges, challenging classical diagnostic criteria based on elevated aldosterone.
Suppressed renin levels play a critical role in detecting PA, underscoring the importance of combined evaluation rather than isolated aldosterone concentration.
A modified aldosterone-to-renin ratio (ARR) formula, involving a correction factor for plasma aldosterone, significantly improves sensitivity with minimal trade-off in specificity.
Enhanced ARR diagnostic performance may facilitate recognition of nonclassic or subtle PA presentations, potentially improving clinical management and outcomes.
