Reevaluating RhD-Positive Whole Blood Use in Trauma Patients with Reproductive Potential: Ethical and Clinical Implications Post-Two Randomized Trials

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Recent randomized control trials demonstrate no survival benefit when using whole blood, typically RhD-positive, over component therapy in prehospital trauma resuscitation.

Transfusing RhD-positive whole blood to RhD-negative patients with reproductive potential poses preventable risks of anti-D alloimmunization and subsequent hemolytic disease of the fetus and newborn.