The traditional Pooled Cohort Equations (PCE) model remains widely used for 10-year ASCVD risk estimation but typically overestimates risk, especially in patients undergoing statin therapy.
The newly developed PREVENT model accounts for statin exposure during follow-up, offering improved risk calibration in treated populations.
Both models demonstrate similar discrimination (C-statistics approximately 0.72-0.73), but differ in calibration depending on statin treatment status.
Clinicians should consider patient statin use when selecting a prediction model to avoid risk underestimation or overestimation and optimize personalized prevention strategies.
