Highlights
- Perioperative inhaled nitric oxide (NO) reduces postoperative acute kidney injury (AKI) incidence in cardiac surgery patients with chronic kidney disease (CKD).
- NO therapy preserves glomerular filtration rate (GFR) six months post surgery, suggesting protective effects against CKD progression.
- Reduced postoperative pneumonia incidence indicates additional benefits of NO beyond renal protection.
- NO administration is safe with no significant adverse hematologic or oxidative stress effects detected.
Background
