Pre-pregnancy obesity in both mothers and fathers independently increases the risk of adult offspring developing metabolic dysfunction associated steatotic liver disease (MASLD).
Biparental overweight or obesity raises the odds of offspring MASLD by nearly fourfold compared to normal BMI parents.
Approximately two-thirds of this increased risk is mediated through cumulative childhood excess adiposity, quantified between ages 7 and 17.
Findings support a life course perspective on MASLD prevention, emphasizing parental health before conception and intervention during childhood.
