Unveiling the TL1A-LTα1β2/IL-22 Axis: A New Therapeutic Target in Crohn’s Disease with Perianal Fistulising Disease

Unveiling the TL1A-LTα1β2/IL-22 Axis: A New Therapeutic Target in Crohn’s Disease with Perianal Fistulising Disease

This study reveals that TL1A-activated CD4+ T cells drive distinct cellular and molecular changes in the rectal mucosa of Crohn's disease patients with perianal fistulising disease (PFD), highlighting a novel TL1A-LTα1β2/IL-22 axis independent of TNF signaling, with important therapeutic implications.
New 2026 EASD Guideline: Practical, Evidence-Based Care for Diabetes Distress in Adults with Type 1 and Type 2 Diabetes

New 2026 EASD Guideline: Practical, Evidence-Based Care for Diabetes Distress in Adults with Type 1 and Type 2 Diabetes

The 2026 EASD guideline provides practical, evidence-based recommendations for routine assessment and management of diabetes distress in adults with type 1 or type 2 diabetes, including validated screening, eight Good Practice Statements, and conditional GRADE recommendations for psychological and technology-based interventions.