Lower baseline neutrophil counts are strongly associated with increased likelihood of type 2 diabetes remission (T2DM) after a 5-year Mediterranean diet intervention, but not with a low-fat diet.
Neutrophil-related ratios normalized to other blood components (NER, NHR) also predict remission and enhance model accuracy.
Responders who achieved remission show significant decreases in neutrophil counts over time with improvements in insulin sensitivity and beta-cell function.
Immune cell profiling may aid patient stratification and prognostication in dietary management of T2DM, especially in those with coronary heart disease.
