Combined hormonal contraceptive (HC) use is associated with a 31% reduction in major adverse cardiovascular events (MACE) among women without a history of PTSD.
The presence of depression or generalized anxiety disorder does not significantly alter the cardiovascular risk profile associated with HC use.
Posttraumatic Stress Disorder (PTSD) acts as a critical moderator, negating the cardiovascular benefits of HCs and trending toward an increased risk (OR 1.68) for MACE.
Deep vein thrombosis (DVT) risk appears independent of the interaction between stress-related psychiatric disorders and HC use in this cohort.
