Intraoperative Iodine Staining During LEEP: A Randomized Trial Challenging Its Routine Use

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This randomized controlled trial uniquely compares loop electrosurgical excision procedure (LEEP) performed with versus without intraoperative Lugol’s iodine staining (IOS). Contrary to expectations, the application of IOS was associated with a significantly higher rate of involved (positive) resection margins. Secondary outcomes indicated reduced postoperative bleeding intensity and duration in the iodine-staining group, but no differences in operative complications, pain, or procedure time. The findings argue against routine use of intraoperative iodine for margin delineation during LEEP.

Study Background