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This double‑blind randomized trial in 80 heterosexual couples (N = 160) integrated repeated intranasal oxytocin, a brief structured partner interaction (Partner Appreciation Task, PAT), and ecological sampling of daily affectionate touch and sexual activity. Intimate physical contact was associated with lower daily cortisol and, when combined with oxytocin, with modestly faster blister wound healing. Effects were small and sensitivity analyses attenuated some findings — suggesting promising but preliminary translational implications.
