Intensity-Modulated Proton Therapy Reduces Acute Toxicity While Maintaining Oncologic Equivalence in Nasopharyngeal Carcinoma: A Five-Year Case-Control Analysis

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IMPT was associated with a significantly lower incidence of grade 2 or higher acute toxicities compared to IMRT (86.6% vs 97.8%, p = 0.009).

There were no statistically significant differences in 5-year cumulative incidence of local or regional failures, progression-free survival (PFS), or overall survival (OS) between the two modalities.