Evaluating the Impact of Parathyroidectomy and Bisphosphonate Therapy on Bone Mineral Density: Insights from a Multi-Institutional Study

Highlight

• Parathyroidectomy leads to a clinically meaningful improvement in total hip bone mineral density (BMD) in nearly half (45.2%) of patients within 3 years post-surgery.
• Bisphosphonate therapy started before or after parathyroidectomy did not significantly increase the rate of meaningful BMD improvement compared to surgery alone.
• The timing and additive benefit of bisphosphonates in enhancing skeletal recovery after parathyroidectomy remain unclear, highlighting a critical need for improved adjuvant therapies.