Parathyroidectomy leads to a clinically meaningful improvement in total hip bone mineral density (BMD) in nearly half (45.2%) of patients within 3 years post-surgery.
Bisphosphonate therapy started before or after parathyroidectomy did not significantly increase the rate of meaningful BMD improvement compared to surgery alone.
The timing and additive benefit of bisphosphonates in enhancing skeletal recovery after parathyroidectomy remain unclear, highlighting a critical need for improved adjuvant therapies.
