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This investigation of over 70,000 adults aged 50 and above, drawn from three large longitudinal European and US studies (HRS, ELSA, SHARE), elucidates complex temporal changes in body composition around the diagnosis of type 2 diabetes (T2D). Key insights include the inverted U-shaped trajectory of BMI peaking 2-4 years before diagnosis, ongoing accumulation of visceral fat with attenuated growth during weight loss phases, and accelerated muscle strength decline among cases versus controls in the SHARE cohort.
