Severe Insulin-Resistant Diabetes (SIRD) and Severe Insulin-Deficient Diabetes (SIDD) subgroups face a nearly three-fold increase in the risk of kidney failure compared to mild age-related diabetes.
The SIRD subgroup presents with the highest baseline prevalence of hypertension, dyslipidemia, and steatotic liver disease, despite having lower HbA1c levels than autoimmune groups.
Mortality risk is significantly elevated in SIDD, SIRD, and Mild Obesity-related Diabetes (MOD) subgroups, largely driven by cardiovascular events, persisting even after adjustment for traditional risk factors.
Subgroup-based classification at the time of diagnosis provides a superior prognostic framework for predicting retinopathy, neuropathy, and heart failure than current glucose-centric models.
Introduction: The Shift Toward Precision Diabetology
