Highlight
- The CONKO-007 trial compared induction chemotherapy plus chemoradiotherapy (CRT) with chemotherapy alone in initially unresectable pancreatic cancer.
- Overall R0 resection rates did not significantly differ between CRT (25%) and chemotherapy arms (18%).
- Among patients who proceeded to surgery, CRT significantly improved R0 resections (69.4% vs 50.0%) and overall resection quality.
- Overall survival was not improved by CRT; however, surgical resection itself was associated with significantly longer survival.
Study Background and Disease Burden
