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1. Blood-based biomarkers (BBM) for neurodegenerative diseases vary considerably with age, genetic, metabolic, and lifestyle factors.
2. APOE ε4 carrier status and serum creatinine levels strongly associate with adverse BBM profiles in midlife and older adults.
3. Several cardiometabolic factors relate negatively with BBM, though their effects are modulated by body mass index (BMI).
4. Significant intergenerational correlations exist for phosphorylated Tau-217, GFAP, and neurofilament light chain, predominantly between mothers and offspring, but not for amyloid β42:40 ratio.
