Highlights
- Median survival in genetic frontotemporal dementia (FTD) averages approximately 7 years from symptom onset, with variation by genetic subtype (GRN, C9orf72, MAPT).
- Survival heterogeneity is primarily driven by age at onset, clinical presentation—with motor symptoms portending poorer prognosis—and geographic factors rather than direct genetic group effects.
- Development of an individual-level genetic FTD survival risk index offers potential for more accurate prognostication and patient stratification in clinical trials.
- Motor impairment alongside cognitive and behavioural symptoms should be integrated into prognostic models to better capture disease trajectory in genetic FTD.
Background
Specialty calculators
For clinical reference; use professional judgment.
