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– AAV‑OTOF (Anc80L65 capsid) administered to 10 individuals with autosomal recessive deafness 9 (DFNB9) was well tolerated over 6–12 months and produced large, rapid improvements in auditory thresholds.
– Mean pure‑tone average (PTA) improved from 106 ± 9 dB to 52 ± 30 dB; click and tone‑burst ABR strongly predicted behavioral PTA after 4 months (R2 = 0.68 and 0.73).
