A Century of Change: How Human Innovation Transformed Lung Cancer Treatment

Highlights

  • Lung cancer transitioned from a clinical rarity to the world’s leading cause of cancer death, in part due to changes in smoking habits and advances in diagnostic technology.
  • Therapeutic breakthroughs—from surgery to molecularly targeted agents and immunotherapies—have significantly improved survival in certain subtypes, especially non-small cell lung cancer (NSCLC).
  • Precision medicine now enables treatment tailored to genetic drivers like EGFR, ALK, ROS1, BRAF, RET, MET, and KRAS, as well as immune checkpoint inhibition and antibody-drug conjugates.
  • Despite progress, late-stage diagnosis and drug resistance remain key challenges, highlighting the need for continued innovation and early detection.

Background and Disease Burden

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