Alginate dietary fiber promotes recovery from colitis by enhancing mucosal healing via a microbiota-dependent taurine pathway.
Alginate enriches taurine-releasing bacteria, increasing intestinal taurine and stimulating epithelial regeneration mediated by CYP enzymes.
Gene knockout murine models (Slc6a6-/-, Cyp2c55-/-) confirm taurine uptake and CYP2C enzyme involvement in therapeutic effects.
A randomized clinical trial in ulcerative colitis showed biological markers consistent with mechanistic pathways, although the primary endpoint was not met.
