Vitamin B12 – Medxy AI

Periconceptional Vitamin B12 and Folate Levels in Parents Linked to Birth Defect Risk Reduction: Insights from a Large Prospective Cohort

By MedXY 09/10/2026

This Shanghai cohort study reveals that higher parental vitamin B12 and maternal postconception RBC folate levels associate with significantly lower birth defect prevalences, highlighting novel nutritional targets beyond maternal folic acid for perinatal care.

Hematology-Oncology Internal Medicine news

Unveiling BPNT1 Mutations as a Novel Cause of Vitamin B12-Dependent Megaloblastic Anemia

By MedXY 08/07/2026

Biallelic loss-of-function mutations in BPNT1 are identified as a new genetic cause of vitamin B12-dependent megaloblastic anemia, linked to disrupted ribosome biogenesis and impaired ileal vitamin B12 absorption in mouse models.

Anesthesiology Hematology-Oncology news

Preoperative Anaemia Is Common and Multifactorial: Iron Deficiency Dominates but B12 and Folate Shortfalls Matter

By MedXY 11/30/2025

The ALICE international cohort found 31.7% prevalence of preoperative anaemia in major surgery patients; iron deficiency accounted for 55% of confirmed causes, with notable contributions from vitamin B12 and folate deficiencies. Broader preoperative testing and tailored management are needed.

Diabetes & Endocrinology Internal Medicine news

Metformin Selectively Lowers Vitamin B12 but Not Other Vitamin Levels: Clinical Implications for Long-Term Therapy

By MedXY 11/17/2025

A 200‑patient cross‑sectional study found metformin use tripled the odds of vitamin B12 deficiency without affecting vitamins A, B1, B6, B9, C or E, highlighting the need for targeted B12 monitoring in long‑term metformin therapy.

Clinical Updates Internal Medicine Neurology news

Higher Vitamin B12 from Mid- to Late Life Is Associated with Slower Cognitive Decline: Evidence and Implications

By MedXY 11/05/2025

Elevated vitamin B12 levels from mid- to late life correlate with reduced rates of cognitive decline across language, memory, and executive function domains, independent of folate status, highlighting potential preventative strategies against age-related cognitive impairment.

Family Medicine & Nutrition Oncology Specialties

Vitamin B12 Supplementation Halves Risk of Chemotherapy-Induced Hand-Foot Syndrome in Early Breast Cancer Patients

By MedXY 09/25/2025

A phase 3 trial finds high-dose oral vitamin B12 significantly reduces moderate-to-severe hand-foot syndrome in women receiving capecitabine chemotherapy, without increasing toxicity, offering a safe and convenient preventive option.

Family Medicine & Nutrition Specialties

Hypervitaminosis B12 and Mortality Risk: Unraveling the Controversy Through a Global Systematic Review and Meta-Analysis

By MedXY 08/18/2025

A comprehensive meta-analysis reveals that elevated serum vitamin B12 levels do not conclusively predict increased all-cause mortality risk in adults, highlighting the complexity and heterogeneity of existing research.

Family Medicine & Nutrition news Specialties

Affordable Vitamin B12: Potential Benefits for Improving Four Health Conditions

By MedXY 08/06/2025

Vitamin B12, an inexpensive supplement, plays a crucial role in health, especially for the elderly, by potentially improving anemia, cognitive decline, cardiovascular risks, and nerve health.

Family Medicine & Nutrition Internal Medicine news

The Essential Role of Vitamin B12: Recognizing Symptoms and Managing Deficiency

By MedXY 07/26/2025

Vitamin B12 deficiency can lead to serious health issues, including anemia and cognitive decline. Learn who is at risk and how to manage this deficiency.