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tumour-draining lymph nodes

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SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes
Posted inGastroenterology news Oncology

SPP1-Positive Macrophages Shape Immunosuppression in Colorectal Cancer Lymph Nodes

Posted by MedXY By MedXY 06/17/2026
Single-cell profiling of colorectal cancer lymph nodes revealed an SPP1–CD44–NF-κB1 pathway that promotes CD137+ regulatory T-cell maturation and may be therapeutically targetable.
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