Hormones and Aging, Not Just Diet: Unmasking the Sex-Specific Drivers of Plasma Ketone Levels
A large-scale analysis of the PREVEND cohort reveals that fasting β-hydroxybutyrate levels are primarily driven by sex-specific factors: oral contraceptives and menopause in women, and aging in men, challenging the dietary-centric view of ketosis and highlighting endocrine influences on metabolism.