Posted inAllergy & Immunology Gastroenterology news
GWAS of Idiopathic Achalasia Reveals a Strong HLA Class II–Mediated Immune Aetiology and T-Cell Involvement
A first large GWAS in 4,602 idiopathic achalasia patients implicates class II HLA variation, PTPN22, TNFSF loci and a memory CD8+ T-cell subtype in disease pathogenesis, supporting an immune-mediated aetiology and offering routes for mechanistic work and risk stratification.