Preoperative Single‑Fraction Ablative Radiotherapy for Early HR+ Breast Cancer: Low Toxicity, High Pathologic Responses with Delayed Surgery
A phase 1 trial reports tolerable single‑fraction preoperative stereotactic partial‑breast irradiation (30–38 Gy) with low toxicity, preserved cosmesis, and high pathologic complete response rates when surgery was delayed beyond ~9 months on endocrine therapy.