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PAP intolerance

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AD109 (Aroxybutynin and Atomoxetine): A Promising Oral Therapy for Obstructive Sleep Apnea in PAP-Intolerant Patients
Posted innews Respiratory

AD109 (Aroxybutynin and Atomoxetine): A Promising Oral Therapy for Obstructive Sleep Apnea in PAP-Intolerant Patients

Posted by MedXY By MedXY 07/02/2026
The SynAIRgy phase 3 trial demonstrated that the fixed-dose combination of aroxybutynin and atomoxetine (AD109) significantly reduces airway obstruction and improves oxygenation in obstructive sleep apnea patients unable to tolerate positive airway pressure therapy.
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