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Oncogenic DHX15 Mutation Drives Mitochondrial Metabolism to Sustain Leukemia Stemness in AML
Posted inHematology-Oncology news Oncology

Oncogenic DHX15 Mutation Drives Mitochondrial Metabolism to Sustain Leukemia Stemness in AML

Posted by By MedXY 08/24/2026
A hotspot DHX15R222G mutation collaborates with AML1-ETO fusion to enhance mitochondrial function and leukemia stem cell activity, leading to poorer prognosis and chemotherapy resistance in AML, unveiling OXPHOS inhibition as a promising targeted therapy.
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