Impact of Clonal Hematopoiesis and Pre-treatment Neutropenia on CAR-T Cell Therapy Outcomes in Hematological Malignancies
Posted inHematology-Oncology news Oncology

Impact of Clonal Hematopoiesis and Pre-treatment Neutropenia on CAR-T Cell Therapy Outcomes in Hematological Malignancies

This study evaluates how clonal hematopoiesis of indeterminate potential (CHIP) and pre-treatment neutropenia affect clinical outcomes and toxicities in patients undergoing CAR-T therapy for hematologic cancers, revealing nuanced risks for specific toxicities without compromising survival outcomes.
Peg-GCSF Primary Prophylaxis Effectively Mitigates Severe Neutropenia and Enhances Quality of Life in mFOLFIRINOX-Treated Pancreatic Cancer
Posted inGastroenterology news Oncology

Peg-GCSF Primary Prophylaxis Effectively Mitigates Severe Neutropenia and Enhances Quality of Life in mFOLFIRINOX-Treated Pancreatic Cancer

A randomized phase 2 trial demonstrates that primary prophylaxis with peg-GCSF significantly reduces grade 3-4 and febrile neutropenia in patients with unresectable pancreatic cancer receiving mFOLFIRINOX, while improving patient-reported quality of life without increasing bone pain.