Posted inGastroenterology news Oncology
PTEN Loss Drives MHC-I Evasion and Checkpoint Resistance in Microsatellite Stable Colorectal Cancer via NRF2-Dependent Autophagy
A Gut study links PTEN deficiency in MSS colorectal cancer to NRF2-driven autophagic loss of MHC-I, impaired CD8+ T-cell surveillance, and resistance to anti-PD-1 therapy, while identifying NRF2 inhibition as a potential sensitizing strategy.