melatonin – Medxy AI

Melatonin’s Impact on Glucose Metabolism: Risk Amplified by MTNR1B Diabetes Variant

By MedXY 08/03/2026

Melatonin impairs glucose tolerance and early insulin secretion, particularly in carriers of the MTNR1B diabetes risk allele, revealing critical mechanisms linking melatonin signaling to diabetes susceptibility and highlighting the need for genotype-based personalized care.

Critical Care Internal Medicine news

Melatonin Does Not Prevent Delirium in the Intensive Care Unit: Insights from a Comprehensive Meta-Analysis

By MedXY 12/28/2025

A recent systematic review and meta-analysis of 13 randomized controlled trials concludes that melatonin fails to reduce the incidence of delirium or mortality in critically ill patients, challenging the routine use of this supplement in the intensive care setting.

Critical Care Internal Medicine news

Melatonin in the ICU Does Not Translate to Reduced Delirium Incidence

By MedXY 12/28/2025

The DEMEL trial found that while 0.3 mg of melatonin achieved a superior pharmacokinetic profile over 3 mg, it failed to reduce delirium incidence or improve clinical outcomes in mechanically ventilated patients compared to placebo.

Family Medicine & Nutrition Neurology news Specialties

Unlocking Better Sleep: How Daily Walnut Consumption Enhances Melatonin Metabolism and Sleep Quality in Young Adults

By MedXY 09/16/2025

A randomized crossover trial shows that daily intake of 40 g walnuts increases urinary 6-sulfatoxymelatonin, reduces sleep latency, and improves global sleep quality in young adults, highlighting walnuts' potential as a natural sleep aid.

news Pediatrics Psychiatry Specialties

Midazolam Outperforms Melatonin as Premedication for Anxiety in Children Undergoing Elective Surgery: Insights from the MAGIC Trial

By MedXY 09/07/2025

The MAGIC trial reveals midazolam’s superior efficacy over melatonin in reducing preoperative anxiety in children undergoing general anaesthesia, despite melatonin’s favorable safety profile. Challenges in recruitment and implications for future research are discussed.

Family Medicine & Nutrition Neurology news Specialties

Unlocking Better Sleep: The Science and Safety of Popular Sleep Supplements

By MedXY 08/18/2025

Explore scientifically supported sleep supplements like melatonin, jujube seed extract, GABA, reishi spore powder, valerian root, ashwagandha, and magnesium, their benefits, risks, and expert guidance for improving sleep quality.