Machine Perfusion

Mitigating Innate Immune Response in Liver Transplantation: Insights from HOPE and NMP Machine Perfusion

By MedXY 10/04/2026

This article reviews how hypothermic oxygenated and normothermic machine perfusion reduce hepatic and systemic inflammation after liver transplantation, improving immune regulation and clinical outcomes.

Gastroenterology General Surgery news

Comparative Real-World Outcomes of Hypothermic Oxygenated and Normothermic Machine Perfusion in Liver Transplantation

By MedXY 09/12/2026

This international cohort study evaluates hypothermic oxygenated perfusion (HOPE) versus normothermic machine perfusion (NMP) in liver transplantation, revealing comparable high graft survival despite differing donor risk profiles and highlighting the need for further research on NMP benefits in high-risk grafts.

General Surgery Nephrology news

Expanding the Horizon of Simultaneous Liver-Kidney Transplantation: Leveraging DCD Donors with Machine Perfusion Technologies

By MedXY 07/08/2026

This nationwide US study analyzes 10,687 simultaneous liver-kidney transplants, highlighting increased use of DCD donors with machine perfusion and comparable outcomes to DBD transplants, supporting broader DCD adoption in selected patients.

Clinical Updates General Surgery news Transplantation

Portal-Venous Hypothermic Oxygenated Perfusion in Liver Transplantation: Evidence Synthesis from the Bridge to HOPE Trial and Global Clinical Landscape

By MedXY 06/04/2026

This review synthesizes findings from the Bridge to HOPE multicenter trial and other recent evidence, demonstrating that portal-venous hypothermic oxygenated perfusion (HOPE) significantly reduces early allograft dysfunction, improves biliary health, and modulates donor immunogenicity in extended-criteria liver transplantation.