Linarin as a Multifaceted Therapeutic Agent for NAFLD: Modulation of PI3K/Akt/mTOR, Autophagy, and Gut Microbiota
Linarin shows promise in mitigating NAFLD by enhancing autophagy via PI3K/Akt/mTOR inhibition, reducing inflammation, and restoring gut microbiota balance, alongside activating the PDE4D/cAMP/PKA/CREB pathway to improve hepatic lipid metabolism and oxidative stress.