Posted inGastroenterology news Oncology
Targeting NSUN6 Deficiency to Overcome Immune Suppression in Pancreatic Cancer: Insights into the KDM5A-CCL2-Macrophage Axis
NSUN6 deficiency in pancreatic cancer promotes immune suppression by enhancing immunosuppressive macrophage infiltration via the KDM5A-CCL2 axis, leading to resistance to immune checkpoint blockade; targeting this pathway offers a promising therapeutic approach.