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Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis
Posted inAllergy & Immunology Gastroenterology news

Colonic GPR15L Emerges as a Microbiota-Shaping Host-Defense Peptide That Protects Against Experimental Colitis

Posted by MedXY By MedXY 06/10/2026
New data identify GPR15L as an epithelial host-defense peptide that reshapes the colonic microbiota, reduces experimental colitis, and may have therapeutic relevance in inflammatory bowel disease.
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Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit
Posted inGastroenterology news Oncology

Targeting MLCK1 May Separate Immune Checkpoint Inhibitor Colitis From Antitumour Benefit

Posted by MedXY By MedXY 05/20/2026
A Gut study identifies MLCK1-driven epithelial barrier failure as a central mechanism in immune checkpoint inhibitor colitis and suggests epicatechin as a barrier-protective strategy that preserves antitumour efficacy in preclinical models.
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